Hazard statement · Health hazards
What does H372 mean?
Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard> .
- Hazard class
- Specific target organ toxicity — Repeated exposure, Hazard Category 1 (STOT RE 1)
- Pictogram
GHS08Health hazard- Signal word
- Danger
Categories and label elements
| CLP abbreviation | Pictogram | Signal word |
|---|---|---|
| STOT RE 1 | GHS08Health hazard | Danger |
Related precautionary statements (P codes)
The precautionary statements that CLP Annex IV assigns to this class. Not all of them go on the label: under CLP Article 28(3), no more than six precautionary statements appear on the label unless the nature and severity of the hazard require more; the selection depends on the product and its users.
Build a label with this class. The free label tool works out the pictogram, the signal word and the P statements for the label from the classes you choose.
When does a mixture need H372?
H372 reaches the label and the safety data sheet of a mixture only when the classes and percentages of its components pass certain limits. The relevant limits in the Chemoris rule file are:
- Threshold method: a STOT RE 1 component at ≥ 10 % gives the mixture the same class. (CLP Annex I Table 3.9.4)
- If a component has a harmonised specific concentration limit (SCL) and meets it, the mixture takes the corresponding class directly.
For a step-by-step worked example see classifying a mixture under CLP.
Where is H372 written in the SDS?
In the SDS, H372 ("Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard> .") first enters Section 2.1 as a classification, written as "STOT RE 1" together with the code. Section 2.2 then gives its full text as a label element. Components that have this class are listed row by row in the Section 3 table; in addition, it appears in Section 11 (toxicological information), under heading 11.1, as a "Classified" line when the class is among the classes of the mixture.
How does H372 appear on the label?
On the label H372 appears with the pictogram GHS08 (health hazard), and it is written with the signal word "Danger". In the Chemoris template Section 2.2 carries at most 8 H statements; if the limit is exceeded the least severe ones are dropped and a warning is shown. For the bottom of the label, 5 P statements are candidates for this class in CLP Annex IV; under CLP Article 28 at most 6 of them are selected.
Where does it appear in the safety data sheet?
- Section 2.1: classification; the class abbreviation and H372 are given together.
- Section 2.2: label elements; H372 with its full text, pictogram and signal word.
- Section 3: composition table; in the row of every component that has this class.
- Section 16: the full text of the H statements cited as codes in earlier sections.
Class criteria and thresholds for H372
The values below come from the Chemoris rule file (CLP Annex I). They show the condition under which H372 arises in a mixture. For physical hazards and other classes that depend on test data, the result comes from the mixture's own measurement, not from component percentages.
| Class | Criterion | Limit / formula | Source |
|---|---|---|---|
| STOT RE 1 | Single-component concentration limit | STOT RE 1 component ≥ 10 % | CLP Annex I Table 3.9.4 |
H372 compared with H373 and H371
The table below puts H372 next to its closest neighbouring statements; the values are read from the rule data.
| Hazard statement | H372 | H373 | H371 |
|---|---|---|---|
| Class abbreviation | STOT RE 1 | STOT RE 2 | STOT SE 2 |
| Pictogram | GHS08 | GHS08 | GHS08 |
| Signal word | Danger | Warning | Warning |
| Precautionary statements assigned | 5 | 3 | 6 |
| Concentration cut-off in a mixture | — | — | — |
The signal word differs: Danger for H372, Warning for H373. Both are shown with the same pictogram (GHS08). The signal word differs: Danger for H372, Warning for H371. Both are shown with the same pictogram (GHS08).
In which SDS sections does H372 appear?
H372 does not stay only in the label section of an SDS; the class itself and the precautionary statements assigned to it shape the content of other sections too. The counts are calculated from the P statements that Annex IV assigns to this class.
| SDS section | Relation to this code |
|---|---|
| 2.1 Classification | Written with the abbreviation STOT RE 1 and the code H372. |
| 2.2 Label elements | H372 appears with its full text, GHS08 (health hazard) and “Danger”. |
| 3 Composition | The class and code show in the row of every component that carries this class. |
| 11 Toxicological information | The health effect is justified here under the relevant endpoint heading. |
| 4 First aid | Of the 5 assigned P statements, 1 belong to the subject of this section: P314. |
| 7 Handling and storage | Of the 5 assigned P statements, 3 belong to the subject of this section: P260, P264, P270. |
| 13 Disposal | Of the 5 assigned P statements, 1 belong to the subject of this section: P501. |
| 16 Other information | The full text of the H statements cited by code is collected here. |
Statements that appear on the label together with H372
H372 is never printed alone on a label; it sits next to the pictogram and the signal word. The Chemoris selection method (response, prevention, storage, disposal in that order; core statements first) gives these first 5 candidates for this class:
| Rank | P code | Type | Priority | Text |
|---|---|---|---|---|
| 1 | P314 | response | core | Get medical advice/attention if you feel unwell. |
| 2 | P260 | prevention | core | Do not breathe dust/fume/gas/mist/vapours/spray. |
| 3 | P264 | prevention | core | Wash … thoroughly after handling. |
| 4 | P270 | prevention | core | Do not eat, drink or smoke when using this product. |
| 5 | P501 | disposal | core | Dispose of contents/container to … |
The GHS08 pictogram and “Danger” are printed together. This ranking applies because a label usually carries at most 6 statements; when a combined statement is selected, its parts are not printed again.
Official EU wording of H372 in other languages
When a product is exported to the EU, the SDS and label are expected in the official language of the Member State where it is placed on the market (REACH Article 31(5)). The table gives the official wording of H372 from the CLP Annex III/IV language versions published in the Official Journal of the European Union. Source: EUR-Lex CELEX 02008R1272-20260701.
| Language | Official wording | Class title | Signal word |
|---|---|---|---|
| German | Schädigt die Organe < alle betroffenen Organe nennen> bei längerer oder wiederholter Exposition < Expositionsweg angeben, wenn schlüssig belegt ist, dass diese Gefahr bei keinem anderen Expositionsweg besteht> . | Spezifische Zielorgan-Toxizität (wiederholte Exposition), Gefahrenkategorie 1 | Gefahr |
| French | Risque avéré d'effets graves pour les organes <indiquer tous les organes affectés, s'ils sont connus> à la suite d'expositions répétées ou d'une exposition prolongée <indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger> . | Toxicité spécifique pour certains organes cibles — Exposition répétée, catégorie de danger 1 | Danger |
| Spanish | Provoca daños en los órganos <indíquense todos los órganos afectados, si se conocen> tras exposiciones prolongadas o repetidas <indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce por ninguna otra vía> . | Toxicidad específica en determinados órganos — Exposiciones repetidas, categoría 1 | Peligro |
| Italian | Provoca danni agli organi <o indicare tutti gli organi interessati, se noti> in caso di esposizione prolungata o ripetuta <indicare la via di esposizione se è accertato che nessun'altra via di esposizione comporta il medesimo pericolo> . | Tossicità specifica per organi bersaglio (esposizione ripetuta), categoria di pericolo 1 | Pericolo |
| Polish | Powoduje uszkodzenie narządów <podać wszystkie znane narządy, których to dotyczy > poprzez długotrwałe lub powtarzane narażenie <podać drogę narażenia, jeżeli udowodniono, że inne drogi narażenia nie stwarzają zagrożenia> . | Działanie toksyczne na narządy docelowe – narażenie powtarzane, kategoria zagrożeń 1 | Niebezpieczeństwo |
| Dutch | Veroorzaakt schade aan organen < of alle betrokken organen vermelden indien bekend > bij langdurige of herhaalde blootstelling < blootstellingsroute vermelden indien afdoende bewezen is dat het gevaar bij andere blootstellingsroutes niet aanwezig is >. | Specifieke doelorgaantoxiciteit bij herhaalde blootstelling, gevarencategorie 1 | Gevaar |
| Portuguese | Afecta os órgãos < ou indicar todos os órgãos afectados, se forem conhecidos > após exposição prolongada ou repetida < indicar a via de exposição se existirem provas concludentes de que o perigo não decorre de nenhuma outra via de exposição >. | Toxicidade para órgãos-alvo específicos — exposição repetida, categoria de perigo 1 | Perigo |
| Romanian | Provoacă leziuni ale organelor <sau indicați toate organele afectate, dacă sunt cunoscute> în caz de expunere prelungită sau repetată <indicați calea de expunere, dacă există probe concludente că nicio altă cale de expunere nu provoacă acest pericol> . | Toxicitate asupra unui organ țintă specific – expunere repetată, categoria de pericol 1 | Pericol |
Common mistakes with H372
- Writing unlimited H statements for a multi-class product: in the Chemoris template, Section 2.2 holds at most 8 H statements.
Next steps
To read a statement like H372 correctly on a label and in an SDS, see the guide How to read H and P codes; to pick the class and prepare the label automatically, use the free label tool.
Related hazard statements
Other H statements in the same hazard family as H372 (STOT RE). The difference between categories mostly comes from the degree of severity.
- H373May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard> .
Frequently asked questions
Which pictogram and signal word go with H372 on a label?
For H372 the pictogram is GHS08 (health hazard); it is written with the signal word "Danger".
How many P statements does H372 need?
CLP Annex IV assigns 5 precautionary statements to the class of H372, but under CLP Article 28(3) a label usually carries at most 6 of them; the selection depends on the product and its user.
When does a mixture need H372?
Threshold method: a STOT RE 1 component at ≥ 10 % gives the mixture the same class. If a component has a harmonised specific concentration limit (SCL) and meets it, the mixture takes the corresponding class directly. Details are in the section "When does a mixture need H372?" above.
In which SDS sections does H372 appear?
H372 appears in Sections 2.1 (classification), 2.2 (label), 3 (composition) and 16, and also in 11, 4, 7 and 13.
What is the difference between H372 and H373?
H372 carries Danger and GHS08; H373 carries Warning and GHS08.
Which numerical limits apply to H372 in a mixture?
STOT RE 1: STOT RE 1 component ≥ 10 %.
Source: Regulation (EC) No 1272/2008 (CLP) Annexes I and III; Turkish SEA Regulation (Official Gazette 28848). The statement is the official English text of CLP Annex III. Pictogram and signal word: CLP Annex I Table 3.9.5. Updated: 6 November 2026.
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