Hazard statement · Health hazards
What does H373 mean?
May cause damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard> .
- Hazard class
- Specific target organ toxicity — Repeated exposure, Hazard Category 2 (STOT RE 2)
- Pictogram
GHS08Health hazard- Signal word
- Warning
Categories and label elements
| CLP abbreviation | Pictogram | Signal word |
|---|---|---|
| STOT RE 2 | Warning |
Related precautionary statements (P codes)
The precautionary statements that CLP Annex IV assigns to this class. Not all of them go on the label: under CLP Article 28(3), no more than six precautionary statements appear on the label unless the nature and severity of the hazard require more; the selection depends on the product and its users.
Build a label with this class. The free label tool works out the pictogram, the signal word and the P statements for the label from the classes you choose.
When does a mixture need H373?
Whether a mixture needs H373 is calculated from the classes and concentrations of its components. The values in the rule file for this code are:
- Threshold method: a STOT RE 1 component at ≥ 1 % gives the mixture STOT RE 2 (H373). (CLP Annex I Table 3.9.4)
- Threshold method: a STOT RE 2 component at ≥ 10 % gives the mixture the same class. (CLP Annex I Table 3.9.4)
- If a component has a harmonised specific concentration limit (SCL) and meets it, the mixture takes the corresponding class directly.
For a step-by-step worked example see classifying a mixture under CLP.
Where is H373 written in the SDS?
H373 is tracked in three places of the SDS: the classification line in Section 2.1 ("STOT RE 2"), the label elements in Section 2.2 and the component list in Section 3. Section 16 repeats the explanation of the code. In addition, it appears in Section 11 (toxicological information), under heading 11.1, as a "Classified" line when the class is among the classes of the mixture.
How does H373 appear on the label?
The label elements for H373 are: pictogram GHS08 (health hazard); it is written with the signal word "Warning". In the Chemoris template Section 2.2 carries at most 8 H statements; if the limit is exceeded the least severe ones are dropped and a warning is shown. For the bottom of the label, 3 P statements are candidates for this class in CLP Annex IV; under CLP Article 28 at most 6 of them are selected.
Where does it appear in the safety data sheet?
- Section 2.1: classification; the class abbreviation and H373 are given together.
- Section 2.2: label elements; H373 with its full text, pictogram and signal word.
- Section 3: composition table; in the row of every component that has this class.
- Section 16: the full text of the H statements cited as codes in earlier sections.
Class criteria and thresholds for H373
The values below come from the Chemoris rule file (CLP Annex I). They show the condition under which H373 arises in a mixture. For physical hazards and other classes that depend on test data, the result comes from the mixture's own measurement, not from component percentages.
| Class | Criterion | Limit / formula | Source |
|---|---|---|---|
| STOT RE 2 | Single-component concentration limit | STOT RE 1 component ≥ 1 % | CLP Annex I Table 3.9.4 |
| STOT RE 2 | Single-component concentration limit | STOT RE 2 component ≥ 10 % | CLP Annex I Table 3.9.4 |
H373 compared with H372 and H371
The table below puts H373 next to its closest neighbouring statements; the values are read from the rule data.
| Hazard statement | H373 | H372 | H371 |
|---|---|---|---|
| Class abbreviation | STOT RE 2 | STOT RE 1 | STOT SE 2 |
| Pictogram | GHS08 | GHS08 | GHS08 |
| Signal word | Warning | Danger | Warning |
| Precautionary statements assigned | 3 | 5 | 6 |
| Concentration cut-off in a mixture | — | — | — |
The signal word differs: Warning for H373, Danger for H372. Both are shown with the same pictogram (GHS08). H373 and H371 carry the same signal word (Warning). Both are shown with the same pictogram (GHS08).
In which SDS sections does H373 appear?
H373 does not stay only in the label section of an SDS; the class itself and the precautionary statements assigned to it shape the content of other sections too. The counts are calculated from the P statements that Annex IV assigns to this class.
| SDS section | Relation to this code |
|---|---|
| 2.1 Classification | Written with the abbreviation STOT RE 2 and the code H373. |
| 2.2 Label elements | H373 appears with its full text, GHS08 (health hazard) and “Warning”. |
| 3 Composition | The class and code show in the row of every component that carries this class. |
| 11 Toxicological information | The health effect is justified here under the relevant endpoint heading. |
| 4 First aid | Of the 3 assigned P statements, 1 belong to the subject of this section: P314. |
| 7 Handling and storage | Of the 3 assigned P statements, 1 belong to the subject of this section: P260. |
| 13 Disposal | Of the 3 assigned P statements, 1 belong to the subject of this section: P501. |
| 16 Other information | The full text of the H statements cited by code is collected here. |
Statements that appear on the label together with H373
H373 is never printed alone on a label; it sits next to the pictogram and the signal word. The Chemoris selection method (response, prevention, storage, disposal in that order; core statements first) gives these first 3 candidates for this class:
| Rank | P code | Type | Priority | Text |
|---|---|---|---|---|
| 1 | P314 | response | core | Get medical advice/attention if you feel unwell. |
| 2 | P260 | prevention | core | Do not breathe dust/fume/gas/mist/vapours/spray. |
| 3 | P501 | disposal | core | Dispose of contents/container to … |
The GHS08 pictogram and “Warning” are printed together. This ranking applies because a label usually carries at most 6 statements; when a combined statement is selected, its parts are not printed again.
Official EU wording of H373 in other languages
When a product is exported to the EU, the SDS and label are expected in the official language of the Member State where it is placed on the market (REACH Article 31(5)). The table gives the official wording of H373 from the CLP Annex III/IV language versions published in the Official Journal of the European Union. Source: EUR-Lex CELEX 02008R1272-20260701.
| Language | Official wording | Class title | Signal word |
|---|---|---|---|
| German | Kann die Organe schädigen < alle betroffenen Organe nennen, sofern bekannt> bei längerer oder wiederholter Exposition < Expositionsweg angeben, wenn schlüssig belegt ist, dass diese Gefahr bei keinem anderen Expositionsweg besteht> . | Spezifische Zielorgan-Toxizität (wiederholte Exposition), Gefahrenkategorie 2 | Achtung |
| French | Risque présumé d'effets graves pour les organes <ou indiquer tous les organes affectés, s'ils sont connus> à la suite d'expositions répétées ou d'une exposition prolongée <indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger> . | Toxicité spécifique pour certains organes cibles — Exposition répétée, catégorie de danger 2 | Attention |
| Spanish | Puede provocar daños en los órganos <indíquense todos los órganos afectados, si se conocen> tras exposiciones prolongadas o repetidas <indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce por ninguna otra vía> . | Toxicidad específica en determinados órganos — Exposiciones repetidas, categoría 2 | Atención |
| Italian | Può provocare danni agli organi <o indicare tutti gli organi interessati, se noti> in caso di esposizione prolungata o ripetuta <indicare la via di esposizione se è accertato che nessun'altra via di esposizione comporta il medesimo pericolo> . | Tossicità specifica per organi bersaglio (esposizione ripetuta), categoria di pericolo 2 | Attenzione |
| Polish | Może powodować uszkodzenie narządów <podać wszystkie znane narządy, których to dotyczy > poprzez długotrwałe lub narażenie powtarzane <podać drogę narażenia, jeśli udowodniono, że inne drogi narażenia nie stwarzają zagrożenia> . | Działanie toksyczne na narządy docelowe – narażenie powtarzane, kategoria zagrożeń 2 | Uwaga |
| Dutch | Kan schade aan organen < of alle betrokken organen vermelden indien bekend > veroorzaken bij langdurige of herhaalde blootstelling < blootstellingsroute vermelden indien afdoende bewezen is dat het gevaar bij andere blootstellingsroutes niet aanwezig is >. | Specifieke doelorgaantoxiciteit bij herhaalde blootstelling, gevarencategorie 2 | Waarschuwing |
| Portuguese | Pode afectar os órgãos < ou indicar todos os órgãos afectados, se forem conhecidos > após exposição prolongada ou repetida < indicar a via de exposição se existirem provas concludentes de que o perigo não decorre de nenhuma outra via de exposição >. | Toxicidade para órgãos-alvo específicos — exposição repetida, categoria de perigo 2 | Atenção |
| Romanian | Poate provoca leziuni ale organelor <sau indicați toate organele afectate, dacă sunt cunoscute> în caz de expunere prelungită sau repetată <indicați calea de expunere, dacă există probe concludente că nicio altă cale de expunere nu provoacă acest pericol> . | Toxicitate asupra unui organ țintă specific – expunere repetată, categoria de pericol 2 | Atenție |
Common mistakes with H373
- Mixing up signal words: if any class requires “Danger”, only “Danger” is printed and “Warning” drops out (CLP Article 20(3)).
- Writing unlimited H statements for a multi-class product: in the Chemoris template, Section 2.2 holds at most 8 H statements.
Next steps
To read a statement like H373 correctly on a label and in an SDS, see the guide How to read H and P codes; to pick the class and prepare the label automatically, use the free label tool.
Related hazard statements
Other H statements in the same hazard family as H373 (STOT RE). The difference between categories mostly comes from the degree of severity.
- H372Causes damage to organs <or state all organs affected, if known> through prolonged or repeated exposure <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard> .
Frequently asked questions
Which pictogram and signal word go with H373 on a label?
For H373 the pictogram is GHS08 (health hazard); it is written with the signal word "Warning".
How many P statements does H373 need?
CLP Annex IV assigns 3 precautionary statements to the class of H373, but under CLP Article 28(3) a label usually carries at most 6 of them; the selection depends on the product and its user.
When does a mixture need H373?
Threshold method: a STOT RE 1 component at ≥ 1 % gives the mixture STOT RE 2 (H373). Threshold method: a STOT RE 2 component at ≥ 10 % gives the mixture the same class. Details are in the section "When does a mixture need H373?" above.
In which SDS sections does H373 appear?
H373 appears in Sections 2.1 (classification), 2.2 (label), 3 (composition) and 16, and also in 11, 4, 7 and 13.
What is the difference between H373 and H372?
H373 carries Warning and GHS08; H372 carries Danger and GHS08.
Which numerical limits apply to H373 in a mixture?
STOT RE 2: STOT RE 1 component ≥ 1 %; STOT RE 2: STOT RE 2 component ≥ 10 %.
Source: Regulation (EC) No 1272/2008 (CLP) Annexes I and III; Turkish SEA Regulation (Official Gazette 28848). The statement is the official English text of CLP Annex III. Pictogram and signal word: CLP Annex I Table 3.9.5. Updated: 6 November 2026.
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